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. 2020 Aug 27;11:1961. doi: 10.3389/fimmu.2020.01961

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Copyright © 2020 Corbett, Awad, Wang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diversity and characteristics of MR1-reactive T cells. % refer to those reported in human PBMCs. For subsets with diverse TCRs examples are listed. The lower panel shows cartoon representations of the crystal structures of ternary TCR-MR1-Ag complexes: The typical MAIT A-F7 TRAV1-2-TRBV6-1 TCR-MR1-5-OP-RU (PDB; 6PUC); the atypical TRAV36-TRBV28 TCR-MR1-5-OP-RU (PDB; 5D7L); MR1-autorective M33.64 (TRAV1-2/TRBV6-4) TCR-MR1-5-OP-RU (PDB; 5D5M); and G7 γδ TCR with MR1-5-OP-RU complex (PDB; 6MWR). The MR1 and β2-microglobulin molecules are colored white and pale-cyan, respectively. TRAV1-2 TCRα, light-blue; TRAV6 TCRβ, light-pink; TRAV36 TCRα, violet-purple; TRBV28 TCRβ, sky-blue; TRGV9 TCRγ; lemon, TRDV1 TCRδ, orange. Structural illustration was created using PyMOL Molecular Graphics System, Version 1.8.6, Schrodinger and BioRender.com.