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. 2020 Aug 27;11:1966. doi: 10.3389/fimmu.2020.01966

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Copyright © 2020 Hams, Roberts, Bermingham, Hogan, O'Shea, O'Neill and Fallon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ly6C^hi monocytes are decreased in the blood in the absence of myeloid cell expression of Rora. Blood was collected from age-matched C57Bl6/J WT and C57Bl6/J Rora^sg/sg mice by submandibular bleed. (A) Ly6C expression was quantified on blood CD45⁺CD115⁺ monocytes (n = 8 WT; n = 11 Rora^sg/sg). (B) Rora-YFP expression was quantified on Ly6C^lo and Ly6C^hi blood CD45⁺CD115⁺ monocytes (data is representative of 3 Rora^CreRosa-YFP mice). (C) Ly6C expression was quantified on blood monocytes isolated from Rora^fl/fl and Rora^fl/flLysM^Cre/+ mice (n = 3 Rora^fl/fl; n = 4 Rora^fl/flLysM^Cre/+). Data is representative of mean ± SEM. Student's t-test: ns, not significant, *P < 0.05.