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Final degradative sphingolipid pathway. Abbreviations: SPT – serine palmitoyl transferase, KDHSR – ketodihydrosphingosine reductase, CERS – ceramide synthase, DES – dihydroceramide desaturase, SMase – sphingomylinease, SMS – sphingomyelin synthase, PC – phosphatidylcholine, CK – ceramide kinase, C1PP – ceramide 1-phosphate phosphatase, CDase – Ceramidase, SK – sphingosine kinase, SPPase – sphingosine 1-phosphate phosphatase, S1P lyase – sphingosine-1-phosphate lyase.
