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. 2020 Sep;159:104997. doi: 10.1016/j.phrs.2020.104997

Fig. 6.

Fig. 6

Agathisflavone modulates transcript levels of neuroinflammatory genes. Organotypic cerebellar slices from P10-12 mice were maintained for 7 DIV and then treated with LPC for 15–17 h, followed by agathisflavone (FAB) at 5 or 10 μM for a further 2 DIV, or 0.1% DMSO vehicle. (A, B) Heat map showing the expression of neuroinflammatory genes (A) and respective graphs (B) of RT-qPCR analysis showing the expression of neuroinflammatory genes. (C, D) Heat map showing the expression of regulatory factors (C) and respective graphs (D). Data are expressed as the mean ± SEM or median ± IQR (n = 4); *p < 0.05, **p < 0.01, ***p < 0.001 (comparing control to treatment groups); ‡p < 0.05, ‡‡p < 0.01, ‡‡‡p < 0.001, ‡‡‡‡p < 0.001(comparing LPC-DMSO to LPC+FAB5 and LPC+FAB10); ††p < 0.01 (comparing LPC+FAB5 to LPC+FAB10); samples with Gaussian distribution (bar graphs) were analyzed by one-way ANOVA followed by Tukey’s post-hoc test, non-parametric samples (individual values column graphs) by Kruskal-Wallis followed by Dunns.