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. 2020 Aug 27;11:1326. doi: 10.3389/fphar.2020.01326

Figure 3.

Figure 3

Hesperetin promotes the cisplatin-induced apoptosis of GC cells. (A) Quantitative flow cytometry measurements of apoptosis in GES-1 (control, 4 μg/ml cisplatin, 200 µM hesperetin, or 4 μg/ml cisplatin + 200 µM hesperetin) and HGC-27/DDP (control, 4 μg/ml cisplatin, 50 µM hesperetin, or 4 μg/ml cisplatin + 50 µM hesperetin) (B) Original magnification: 200×. HGC-27 (SGC-7901) cells were treated with control, 4 μg/ml cisplatin, 200 µM hesperetin, or 4 μg/ml cisplatin + 200 µM hesperetin; HGC-27(SGC-7901)/NC and HGC-27(SGC-7901)/PTEN-shRNA were treated with 4 μg/ml cisplatin + 200 µM hesperetin. (C) Quantitative analysis of the apoptosis rate in each group. *P < 0.05 vs. the control; *#P < 0.05 vs. NC cells. (D) Quantitative flow cytometry measurements of apoptosis in GC cells. All the above data are the mean ± SD from an average of three experiments.