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. 2020 Aug 27;11:1326. doi: 10.3389/fphar.2020.01326

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Copyright © 2020 He, Ma, Liu, Deng and Dong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-tumor effects of cisplatin and hesperetin in vivo. (A) Morphology of the subcutaneous implanted tumor. (B) Mean tumor volume at each time point. (C) a. The tumor weight obtained at the end of the experiment. b. The recorded body weights of the mice. (D) A TUNEL assay was performed to detect the apoptotic cells in the tumor tissue. (E) Quantitative analysis of the apoptosis rate in (D). *P < 0.05 vs. the control, *^#P < 0.05 vs. cisplatin alone. All the above data are the mean ± SD from an average of three experiments.