Table 1.
Baseline characteristics of participants with SS SDS
| Characteristics | n | Mean (SD) | 95% CI |
|---|---|---|---|
| Age (y) | 259a | 8.4 (3.2) | 8.0–8.8 |
| Male (%) | 61 | ||
| Preterm (<37 weeks) | 41 | ||
| Birth length SDS | 214 | −0.7 (1.3) | −0.9 to −0.5 |
| SGA for weight (birthweight <2 SDS) | 26 | ||
| Birth weight SDS | 253 | −0.7 (1.2) | −0.8 to −0.5 |
| SGA for length (birth-length <-2 SDS) | 27 | ||
| Microcephalic (visit 1 head circumference < -2 SDS) | 110 | ||
| ≥1 dysmorphic sign | 38 | ||
| ≥1 parent with height SDS <2 | 96 | ||
| Weight SDS | 258 | −2.5 (1.2) | −2.7 to −2.4 |
| Bone age (y) | 250 | 6.1 (3.0) | 5.7–6.5 |
| Height velocity (cm/y) | 199 | 5.0 (1.5) | 4.7–5.2 |
| Sitting height SDS | 165 | −2.2 (2.4) | −2.6 to −1.8 |
| Standing height SDS | 255 | −2.9 (0.7) | −3.0 to −2.8 |
| Midparental height SDS | 248 | −1.3 (0.8) | −1.4 to −1.2 |
The characteristics of participants with SS are shown in this table; the participants were predominantly male, were significantly short with a mean height SDS of -2.9 and had a mean IGF-1 of -2 SDS.
Abbreviations: SDS, standard deviation score; SGA, small for gestational age.
a263 participants were included in the genetic analysis and 259 in the biological analysis.