Table 6.
Clinical/Biological Characteristic | Gene | Position | Corrected P-Value |
---|---|---|---|
Sitting height (↓) | A2M | ENSG_00000175899:g.9110456A > C(Chr12, NCBI38) | 0.01621 |
IGF1 (↓) | TP63 | ENSG_00000073282:g.189873072G > A(Chr3,NCBI38) | 0.04648 |
HC (↓) | DNM3 | ENSG_00000005339:g.172407492C > T(Chr3,NCBI38), rs10752946 | 0.04971 |
Three haplotype tagging SNPs were significantly associated with sitting height, IGF-I, and head circumference, which were all decreased. A2M encodes alpha-2-macroglobulin, a protease inhibitor and cytokine transporter. TP63 encodes tumour protein p63, a member of a family of transcription factors. DNM3 encodes a member of a family of GTP binding proteins that associate with microtubules and are involved in vesicular transport.