. 2020 Aug 25;11:917. doi: 10.3389/fneur.2020.00917

Table 4.

GRADE evaluation results.

Reviews	Interventions	Outcomes	Limitations	Inconsistency	Imprecision	Publication bias	Quality
Liu et al. (39)	Scalp AT + madopar vs. Madopar	Webster scale score	−1^①	0	0	−1^④	L
		UPDRS score	−1^①	−1^②	−1^③	−1^④	VL
		PDSS score	−1^①	0	−1^③	−1^④	VL
Liu et al. (40)	AT + madopar vs. Madopar	Effectiveness	−1^①	0	0	−1^④	VL
		Webster scale score	−1^①	−1^②	0	−1^④	VL
		UPDRS score	−1^①	0	−1^③	−1^④	VL
Ou and Xu (41)	AT + madopar vs. Madopar	UPDRS score	−1^①	−1^②	−1^③	−1^④	VL
		Webster scale score	−1^①	0	−1^③	−1^④	VL
	AT vs. Madopar	UPDRS score	−1^①	−1^②	−1^③	−1^④	VL
		Webster scale score	−1^①	0	−1^③	−1^④	VL
Gui et al. (42)	AT + madopar vs. Madopar	Effectiveness	−1^①	0	0	−1^⑤	L
Yin et al. (43)	AT + madopar vs. Madopar	Effectiveness	−1^①	0	0	−1^⑤	L
Sun and Zhang (44)	AT + madopar vs. Madopar	HAMD score	−1^①	0	0	−1^④	L
		UPDRS I score	−1^①	−1^②	0	−1^④	VL
		UPDRS II score	−1^①	0	0	−1^④	L
		Webster scale score	−1^①	0	0	−1^④	L
Qiang et al. (45)	SEA + medication vs. Medication	UPDRS score	−1^①	−1^②	−1^③	−1^④	VL
		Webster scale score	−1^①	0	−1^③	−1^④	VL
		Effectiveness	−1^①	0	0	0	M
Liu et al. (46)	AT + madopar vs. Madopar	Effectiveness	−1^①	0	0	0	M
		UPDRS score	−1^①	−1^②	0	−1^④	VL
		Adverse events	−1^①	0	−1^③	−1^④	VL
Noh et al. (47)	AT + medication vs. Medication	UPDRS score	−1^①	0	−1^③	0	M
	EA + medication vs. Medication	UPDRS score	−1^①	0	−1^③	0	L
	AT vs. placebo AT	UPDRS score	−1^①	0	−1^③	0	L
Lee and Lim (48)	AT + madopar vs. Madopar	UPDRS score	−1^①	0	0	−1^④	L
		Webster scale score	−1^①	−1^②	−1^③	−1^④	VL
		Effectiveness	−1^①	−1^②	−1^③	−1^④	VL
	AT + madopar vs. Madopar	Webster scale score	−1^①	0	−1^③	−1^④	VL
		Effectiveness	−1^①	0	−1^③	−1^④	VL
	AT vs. no treatment	Webster scale score	−1^①	0	−1^③	−1^④	VL
		Effectiveness	−1^①	0	−1^③	−1^④	VL
Yang et al. (49)	AT vs. Madopar	Effectiveness	−1^①	−1^②	−1^③	−1^④	VL

VL, Very low; L, Low; M, Moderate; H, High. AT, acupuncture therapy; EA, electroacupuncture; SEA, scalp electroacupuncture; UPDRS, Unified Parkinson's Disease Rating Scale; PDSS, Parkinson's Disease Sleep Scale; HAMD, Hamilton Depression Rating Scale;

^①:

The experimental design had a large bias in random, distributive findings or was blind.

^②:

The confidence intervals overlapped less, the P-value for the heterogeneity test was very small, and the I² was larger.

^③:

The confidence interval was not narrow enough.

^④:

Fewer studies were included, and there may have been greater publication bias.

^⑤:

Funnel graph asymmetry.