Table 1: Summary of serum chemistry analyses from loss of ANK and/or ENPP1.
Sera from 60dpn male and female mice were analyzed. Data are presented as mean± standard deviation. Compared to WTs and Ank KOs, alkaline phosphatase levels in Enpp1asj/asj mice were significantly higher (p<0.05), whereas dKO mice alkaline phosphatase levels trended higher. Serum calcium, phosphorous, sodium, potassium, and magnesium levels were comparable between WTs and all KOs.
| WT | Ank KO | Enpp1asj/asj | dKO | |
|---|---|---|---|---|
| Alkaline Phosphatase (U/L) | 233.00 ± 50.06 | 239.20 ± 51.03 | 320.50 ± 70.83* | 287.60 ± 58.08 |
| Calcium (mmol/L) | 2.05 ± 0.51 | 1.91 ± 0.35 | 1.96 ± 0.61 | 1.86 ± 0.38 |
| Phosphorous (mg/dL) | 16.38 ± 2.97 | 13.74 ± 3.49 | 14.79 ± 5.50 | 16.81 ± 6.62 |
| Sodium (mmol/L) | 617.60 ± 18.24 | 617.50 ± 10.01 | 618.90 ± 11.48 | 615.20 ± 13.39 |
| Potassium (mmol/L) | 16.48 ± 5.50 | 16.25 ± 6.39 | 17.43 ± 7.74 | 20.56 ± 9.10 |
| Magnesium (mmol/L) | 1.71 ± 0.31 | 1.52 ± 0.19 | 1.76 ± 0.26 | 1.73 ± 0.23 |