Table 5.
Impact of Hib vaccine on admissions and in-hospital deaths related to respiratory infections among children aged under 3 years old.
| Cases | Population | Absolute risk * (95% CI) | ARR* | Relative risk (95% CI) | RRR (95% CI) | NNT | P | ||
|---|---|---|---|---|---|---|---|---|---|
| Hib Pneumonia | |||||||||
| Protocol 1 | Vaccinated | 121 | 1121344 | 10.7 (8.86; 12.71) | 0.84 | 0.92 (0.74;1.15) | 0.492 | ||
| Unvaccinated | 261 | 2242688 | 11.6 (10.2; 13.0) | ||||||
| Protocol 2 | Vaccinated | 9 | 1121344 | 0.80 (0.027; 1.30) | 10.83 | 0.068 (0.035;0.13) | 0.99 (0.94;0.99) | 9230 (7773;11359) | < 0.0001 |
| Unvaccinated | 261 | 2242688 | 8.17 (7.31;9.03) | ||||||
| Acute otitis media | |||||||||
| Protocol 1 | Vaccinated | 11 | 1121344 | 0.98 (0.40;1.56) | 0.49 | 0.66 (0.33;1.32) | 0.24 | ||
| Unvaccinated | 33 | 2242688 | 1.47 (0.96;1.97) | ||||||
| Protocol 2 | Vaccinated | 5 | 1121344 | 0.44 (0.05;0.84) | 1.02 | 0.30 (0.11;0.77) | 0.69 (0.22;0.88) | 9751 (55946;379283) | 0.012 |
| Unvaccinated | 33 | 2242688 | 1.47 (0.96;1.97) | ||||||
| Deaths all causes aged <3 years | |||||||||
| Protocol 1 | Vaccinated | 2 | 1121344 | 0.17 (0.06;0.43) | 0.83 | 0.16 (0.04,0.70) | 0.83 (0.29;0.96) | 112135 (65703;382310) | 0.0149 |
| Unvaccinated | 24 | 2242688 | 1.07 (0.64; 1.49) | ||||||
| Protocol 2 | Vaccinated | 0 | 1121344 | 0 | 1.07 | 0.0408 (0.002;0.67) | 0.99 | 95434 (60030;232629) | 0.0252 |
| Unvaccinated | 24 | 2242688 | 1.07 (0.64; 1.49) | ||||||
*: per 100,000 inh; unvaccinated cohort: patients born between 2005 and 2011; vaccinated by protocol 1: patients born between 2002 and 2005, with Hib monovalent vaccine at 3, 4, 6 months; vaccinated by protocol 2: patients born after 2011, with a Hib pentavalent combination vaccine at 2, 3 and 6 months; ARR: Absolute Risk Reduction; RRR: relative risk reduction; NNT: Number Needed to Treat