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. 2020 Aug 29;10(23):10680–10696. doi: 10.7150/thno.44250

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miR-339-5p ameliorates intestinal I/R injury and oxidative stress in vivo. C57BL/6 mice received tail vein injections of ago-339 or ago-NC for 3 consecutive days. They were then subjected to 45 min of intestinal ischemia followed by 4 h of reperfusion on the fourth day after injection. (A) miR-339-5p expression levels (n=8). (B) H&E staining and histological injury scoring (Chiu's score) of the intestinal mucosa. Scale bar, 100 µm (n=8). (C) Serum I-FABP levels (n=8). (D) H₂O₂ and MDA content in the intestine (n=8). (E) Mitochondrial H₂O₂ levels in the intestine (n=8). (F) p66Shc, MnSOD, catalase and NOX2 protein expression (n=3). *P<0.05, **P<0.01. The values represent the mean ± SD.