Skip to main content
. 2020 Aug 29;10(23):10680–10696. doi: 10.7150/thno.44250

Figure 7.

Figure 7

Inhibition of circ-PRKCB attenuates intestinal oxidative damage induced by I/R. (A) C57BL/6 mice were intravenously injected with si-circ-PRKCB or si-NC. 24 h after injection, qRT-PCR assays were conducted to determine circ-PRKCB and PRKCB mRNA expression (n=5). (B-G) C57BL/6 mice were intravenously injected with si-circ-PRKCB#3 or si-NC. They were then subjected to intestinal I/R 24 h after injection. (B) circ-PRKCB expression levels (n=8). (C) H&E staining and histological injury scoring (Chiu's score) of the intestinal mucosa. Scale bar, 100 µm (n=8). (D) Serum I-FABP levels (n=8). (E) H2O2 and MDA content in the intestine (n=8). (F) Mitochondrial H2O2 levels in the intestine (n=8). (G) p66Shc, MnSOD, catalase and NOX2 protein expression (n=3). *P<0.05, **P<0.01. The values represent the mean ± SD.