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. 2020 Aug 25;10(23):10634–10651. doi: 10.7150/thno.44278

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High methylation levels of the LINC00261 promoter are observed in PC patients and are correlated with poor prognosis. (A) Methylation levels of LINC00261 in the gene body and the promoter region in PC (N=28) and ANT tissues (N=18). (B) Venn diagram of significant differential methylation sites (CG) in LINC00261 in the three GEO datasets. The cg12179011 was in the promoter region, others were in the gene body. (C) LINC00261 expression as assessed by qRT-PCR in PC and ANT tissues. (D) Validation of the methylation level (cg12179011) in PC and ANT tissues by pyrosequencing. (E) Correlation analysis of LINC00261 expression and the cg12179011 methylation level. (F) Kaplan-Meier analysis of overall survival of PC patients stratified by the methylation level (cg12179011, the study group was dichotomized using the cg-value:1.5) using TCGA data. (G) LINC00261 expression in PC cells after treatment with DAC and AZA (*P < 0.05, **P < 0.01, ***P < 0.001).