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. 2020 Aug 29;10(23):10712–10728. doi: 10.7150/thno.46143

Figure 2.

Figure 2

Microvesicles secreted by M2 macrophages can be incorporated into VSMCs. (A) Schematic diagram of co-culture of macrophages and VSMCs. (B) Naive (M0) macrophages, LPS+IFN-γ-stimulated (M1) macrophages and IL-4+IL-13-stimulated (M2) macrophages incubated with DII were co-cultured with A7R5 incubated with DIO in a Transwell (membrane pore = 0.4 µm) plate for 24 h. The white arrow indicates where DII accumulates in the VSMCs. Scale bar: 100 µm. (C) XZ and YZ side views of the A7R5 (green) co-cultured with M2 macrophage (red). Scale bar: 100 µm.