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(a) Illustration of SARS-CoV RBD subunit S1. (b) Sequence alignment between SARS-CoV RBD219-N1 and SARS-CoV-2 spike protein. The RBM region is circled in green. An example of a neutralizing conformational epitope consisting S343–367, 373–390 and 411–428 (reported by Bian et al.) is circled in blue, indicating neutralizing epitopes do not have to be within RBM.7
