Table 2.
Mother-to-child transmission of HBV in children of HBV-infected mothers after neonatal immunoprophylaxis.
| No of HBsAg+ children/no of children (%) |
||||
|---|---|---|---|---|
| Region | Child birth year | Maternal HBeAg(−) | Maternal HBeAg(+) | No of HBsAg+ children/total no of children (%) |
| Singapore86 | 1980s | 0/670 (0) | 41/345 (11.88) | 41/1015 (4.0) |
| Taiwan87 | 1996–2008 | 4/1773 (0.23)a | 54/583 (9.26) | 58/2356 (2.5) |
| Taiwan88 | 2007–2013 | 0/364 (0) | 19/162 (11.7)b | 19/526 (3.6) |
| China, south89 | 2006–2010 | 0/887 (0) | 21/473 (4.4) | 21/1360 (1.5) |
| China, northwest90 | 2008–2012 | 0/751 (0) | 39/435 (8.97) | 39/1186 (3.3) |
| China, northeast91 | 2012–2015 | 0/565 (0) | 16/306 (5.2) | 16/871 (1.8) |
| China, central and east92 | 2010–2012 | 0/758 (0) | 20/419 (4.8) | 20/1177 (1.7) |
| China, east93 | 2012–2015 | 0/126 (0) | 6/164 (3.7) | 6/290 (2.1) |
| Hong Kong94 | 2014–2016 | 0/486 (0) | 7/155 (4.5) | 7/641 (1.1) |
| USA95 | 1997–2010 | 1/2317 (0.04) | 21/624 (3.37) | 22/2941 (0.7) |
| USA96 | 2007–2013 | 0/772 (0) | 12/362 (3.3) | 12/1134 (1.1) |
aThree of the four HBV-infected children were not administered HBIG after birth.
bAtleast 10 of the 19 HBV-infected children were injected with hepatitis B vaccine within 2–20 d after birth, but not within 24 h after birth (Wen WH, Chang MH, Zhao LL, et al. J Hepatol. 2013;59:24–30.).