Table 1.
Comparison between TP53 genetic mutations and p53 immunohistochemistry
| TP53 mutation | p53 expression by IHC |
Total | p-value | ||
|---|---|---|---|---|---|
| Strong | Negative | Weak | |||
| Mutation status | < .001 | ||||
| Wild-type | 1 (2.9) | 12 (44.4) | 55 (93.2) | 68 (56.7) | |
| Mutation present | 33 (97.1) | 15 (55.6) | 4 (6.8) | 52 (43.3) | |
| Variant summary | < .001 | ||||
| Wild-type | 1 (2.9) | 12 (44.4) | 55 (93.2) | 68 (56.7) | |
| Missense | 30 (88.2) | 0 | 3 (5.1) | 33 (27.5) | |
| Other | 3 (8.9) | 15 (55.6) | 1 (1.7) | 19 (15.8) | |
| Stop-gained | 2 (5.9) | 3 (11.1) | 1 (1.7) | 6 (5.0) | |
| Splice region | 0 | 5 (18.5) | 0 | 5 (4.2) | |
| Frameshift | 0 | 7 (25.9) | 0 | 7 (5.8) | |
| In-frame deletion | 1 (2.9) | 0 | 0 | 1 (0.8) | |
| Clinical significancea | < .001 | ||||
| Wild-type | 1 (2.9) | 12 (44.4) | 55 (93.2) | 68 (56.7) | |
| Pathogenic or likely pathogenic | 22 (64.7) | 13 (48.1) | 2 (3.4) | 37 (30.1) | |
| Uncertain significance | 5 (14.7) | 2 (7.4) | 1 (1.7) | 8 (6.7) | |
| Conflicting interpretation | 6 (17.6) | 0 | 1 (1.7) | 7 (5.8) | |
| Total | 34 | 27 | 59 | 120 | |
Values are presented as number (%).
a
According to the ClinVar and OncoKB databases accessed on March 18, 2020.