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. 2020 Jul 29;54(5):396–410. doi: 10.4132/jptm.2020.06.10

Table 3.

Macroscopic and histological classification on the spectrum of pathology in the cardiac sarcoidosis and cardiac fibrosis in the literature

Morphologic patterns
1. Macroscopic classification of myocardial lesions in cardiac sarcoidosis [25]
- Spotty pattern
- Conglomerate band-like pattern
- Dendritic pattern
2. Histologic features of myocardial lesions in cardiac sarcoidosis [25]
- Exudative type: marked lymphocytic infiltration, diffuse edema, collection of histiocytes in the interstitium
- Granuloma type: typical epithelioid-cell-granuloma formation with giant cells and lymphocytes
- Combined type: some atrophic epithelioid-cell-granulomatous and fibrous change
- Fibrotic type: the myocardial tissue replaced by fibro-hyaline changes, with sparse lymphocytic infiltration.
3. Phases of the lesion in cardiac sarcoidosis [36]
- Early (primarily lymphocytic) phase: areas indistinguishable from lymphocytic myocarditis
- Intermediate (primarily granulomatous) phase: active granulomatous lesion
- Late (primarily scar) phase: areas composed predominantly of scar