Table 4.

Top four challenges and barriers to effective clinical trials as perceived by health professionals, patients, and their caregivers—for the full list, see Mathur et al. (2015) [84]

Scientists and other health professionals	Patients and caregivers
Lack of funding	Risk of potential adverse consequences and potential side effects
Lack of administrative support and time available to manage the trial	Disruption to normal medication regimen
Slow and difficult recruitment of people	Prospect of receiving a placebo instead of the active drug
Lack of practical support	Upheaval and inconvenience to life that trial participation would cause