Table 4.
Diseases potentially linked to the use of chloroquine/hydroxychloroquine + azithromycin combination (SetAnalyzer CTD tool, p-value: 0.01).
| Disease | Disease Categories | Corrected p-value | Number of genes | Annotated Genes |
|---|---|---|---|---|
| Inflammation | Pathology (process) | 3.24e-21 | 11 | CCL2, CCL3, CCL4, CXCL2, CXCL8, ICAM1, IL1B, IL6, PTGS2, TNF, TNFAIP3 |
| Brain Ischemia | Cardiovascular disease Nervous system disease |
1.28e-20 | 10 | CCL2, CCL3, CCL4, CXCL2, ICAM1, IL1B, IL6, NFKBIA, PTGS2, TNF |
| Reperfusion Injury | Cardiovascular disease Pathology (process) |
1.09e-18 | 10 | CCL2, CCL3, CXCL1, CXCL2, CXCL8, ICAM1, IL1B, IL6, PTGS2, TNF |
| Cardiovascular Diseases | Cardiovascular disease | 1.15e-17 | 13 | CCL2, CCL3, CCL4, CXCL1, CXCL2, CXCL3, CXCL8, ICAM1, IL1B, IL6, NFKBIA, PTGS2, TNF, TNFAIP3, |
| Cerebrovascular Disorders | Cardiovascular disease Nervous system disease |
2.12e-17 | 10 | CCL2, CCL3, CCL4, CXCL2, ICAM1, IL1B, IL6, NFKBIA, PTGS2, TNF |
| Myocardial Ischemia | Cardiovascular disease | 4.58e-17 | 11 | CCL2, CCL3, CCL4, CXCL2, CXCL8, ICAM1, IL1B, IL6, NFKBIA, PTGS2, TNF |
| Skin and Connective Tissue Diseases | Skin disease | 1.03e-16 | 14 | CCL2, CCL4, CXCL1, CXCL2, CXCL3, CXCL8, HCAR3, ICAM1, IL1B, IL6, NFKBIA, PTGS2, TNF, TNFAIP3 |
| Immune System Diseases | Immune system disease | 2.93e-16 | 13 | CCL2, CCL3, CCL4, CXCL1, CXCL2, CXCL8, ICAM1, IL1B, IL6, NFKBIA, PTGS2, TNF, TNFAIP3 |
| Hypersensitivity | Immune system disease | 7.40e-16 | 10 | CCL2, CCL3, CCL4, CXCL1, CXCL2, ICAM1, IL1B, IL6, PTGS2, TNF |
| Skin Diseases | Skin disease | 1.19e-15 | 13 | CCL2, CCL4, CXCL2, CXCL3, CXCL8, HCAR3, ICAM1, IL1B, IL6, NFKBIA, PTGS2, TNF, TNFAIP3 |
| COVID19a | Respiratory tract disease Viral disease |
3.41e-12 | 5 | CCL2, CCL3, IL1B, IL6, TNF |
a
Was not among the top 10 related diseases.