Table 1.
Patient characteristics
| Category | Variable | Value |
|---|---|---|
| Number of patients | 471 | |
| Length of hospital stay: days, median (IQR) | 16 (9 – 26) | |
| Length of ICU stay: days, median (IQR) | 9 (5 – 16) | |
| M | In-hospital mortality: n (%) | 128 (27.2%) |
| B | Burst Suppression Burden: median % (IQR) | 9% (0% – 60%) |
| D | Propofol: mg/kg, median (IQR) | 230.5 (86.7 – 570.4) |
| Patient covariates including critical illness (C) | Age: year, median (IQR) | 61 (50 – 72) |
| Gender: n (%) | Female 233 (49.5%); Male 238 (50.5%) | |
| Smoker: n (%) | 225 (47.8%) | |
| Alcohol: n (%) | 125 (26.5%) | |
| Substance abuse: n (%) | 57 (12.1%) | |
| APACHE II: median (IQR) | 23 (20 – 27) | |
| CCI: median (IQR) | 3 (1 – 6) | |
| Initial Glasgow Coma Scale score: median (IQR) | 7 (3 – 13) | |
| Premorbid modified Rankin Score: median (IQR) | 0 (0 – 2) | |
| Structural brain injury: n (%) | 295 (62.6%) | |
| Hypertension: n (%) | 252 (53.5%) | |
| Respiratory failure: n (%) | 182 (38.6%) | |
| Seizures / status epilepticus on presentation: n (%) | 106 (22.5%) | |
| Hemorrhagic stroke: n (%) | 94 (20.0%) | |
| Cardiovascular accident: n (%) | 92 (19.5%) | |
| Subarachnoid hemorrhage: n (%) | 83 (17.6%) | |
| Septic shock: n (%) | 76 (16.1%) | |
| Toxic metabolic encephalopathy: n (%) | 74 (15.7%) | |
| History of seizure: n (%) | 72 (15.3%) | |
| Subdural hematoma: n (%) | 49 (10.4%) | |
| CNS infection or inflammation: n (%) | 48 (10.2%) | |
| Ischemic stroke: n (%) | 40 (8.5%) | |
| Cardiac failure: n (%) | 39 (8.3%) | |
| Renal failure: n (%) | 35 (7.4%) | |
| Brain tumor: n (%) | 30 (6.4%) | |
| Brain Surgery: n (%) | 29 (6.2%) | |
| Malignancy solid tumors hematologic: n (%) | 27 (5.7%) | |
| Liver failure: n (%) | 24 (5.1%) | |
| Primary psychiatric disorder: n (%) | 20 (4.2%) | |
| CNS Cancer: n (%) | 15 (3.2%) | |
| Endocrine emergency: n (%) | 10 (2.1%) | |
| Primary hematological disorder: n (%) | 9 (1.9%) | |
| Systemic hemorrhage: n (%) | 3 (0.64%) |