Table 2.
The patient characteristics and propofol exposure for the representative (“base case”) patients
| Variable | Mild Illness | Severe Illness |
|---|---|---|
| Age (year) | 30.5 | 83 |
| Gender | Female | Female |
| Smoker | No | No |
| Alcohol | No | No |
| Substance abuse | No | No |
| APACHE II | 15 | 26 |
| CCI | 0 | 8 |
| Initial Glasgow Coma Scale score | 12 | 3 |
| Premorbid modified Rankin Score | 0 | 5 |
| Structural Brain Injury | No | Yes |
| Hypertension | No | No |
| Respiratory failure | Yes | No |
| Seizure or Status Epilepticus | No | Yes |
| Hemorrhagic stroke | No | No |
| Cardiovascular accident | No | No |
| Subarachnoid hemorrhage | No | No |
| Septic shock | No | No |
| Toxic metabolic encephalopathy | No | No |
| History of Seizure | No | No |
| Subdural hematoma | No | No |
| CNS infection or inflammation | Yes | No |
| Ischemic stroke | No | Yes |
| Cardiac failure | No | Yes |
| Renal failure | No | No |
| Brain tumor | No | No |
| Brain Surgery | No | No |
| Malignancy solid tumors hematologic | No | No |
| Liver failure | No | No |
| Primary psychiatric disorder | No | No |
| CNS cancer | No | No |
| Endocrine emergency | No | No |
| Primary hematological disorder | No | No |
| Systemic hemorrhage | No | No |
| Propofol (mg/kg) | 284.1 | 1315.5 |