Table 2.

AA GWAS analysis suggests OS-specific risk alleles.

Characteristics					AA OS v HC			AA CC			AA OS v NOS
CHR	BP	SNP	Gene	Minor Allele	OR	95% CIs	P	OR	95% CIs	P	OR	95% CIs	P
3	65690367	rs1499506	MAGI1	C	0.51	0.40–0.64	1.2×10^−8	0.89	0.79–1.00	4.7×10^−2	0.49	0.38–0.64	9.1×10^−8
3	65690647	rs4437178	MAGI1	T	0.51	0.40–0.64	1.2×10^−8	0.89	0.79–1.00	4.1×10^−2	0.49	0.38–0.64	1.4×10^−7
3	65690975	rs59337986	MAGI1	CA	0.51	0.40–0.64	1.2×10^−8	0.89	0.79–1.00	4.1×10^−2	0.49	0.38–0.64	1.4×10^−7
3	65691043	rs17073522	MAGI1	G	0.51	0.40–0.64	1.2×10^−8	0.89	0.79–1.00	4.1×10^−2	0.49	0.38–0.64	1.4×10^−7
3	65691280	rs7618480	MAGI1	T	0.51	0.40–0.64	1.2×10^−8	0.89	0.79–1.00	4.1×10^−2	0.49	0.38–0.64	1.4×10^−7
3	65691371	rs7640824	MAGI1	A	0.51	0.41–0.65	2.3×10^−8	0.90	0.80–1.01	6.1×10^−2	0.49	0.38–0.64	1.5×10^−7
3	65692374	rs17073533	MAGI1	G	0.51	0.41–0.65	1.3×10^−8	0.90	0.80–1.01	6.1×10^−2	0.50	0.39–0.64	8.3×10^−8
18	14184043	rs4101176	ANKRD20A5P	A	2.55	1.83–3.57	4.3×10^−8	1.35	1.07–1.70	1.1×10^−2	2.05	1.36–3.09	6.5×10^−4
18	14186391	rs543143	ANKRD20A5P	C	2.53	1.89–3.38	5.2×10^−10	1.41	1.17–1.71	4.3×10^−4	1.93	1.36–2.74	2.33×10^−4
20	29650348	rs138887197	FRG1BP	T	1.86	1.50–2.30	1.2×10^−8	1.25	1.10–1.41	6.5×10^−4	1.72	1.32–2.24	6.25×10^−5
22	48727259	rs133666	NA	G	1.79	1.45–2.20	3.4×10^−8	1.17	1.03–1.33	1.8×10^−2	1.90	1.47–2.45	1.08×10^−6

To be defined as an OS-specific SNP, the variant had to be significant (p<5×10⁻⁸) in OS compared to controls. Known characteristics of each variant are included: chromosome (CHR), base pair (BP), reference SNP (SNP), and closest gene. Bolded p values indicate genome-wide significance. Italicized p values indicate that to achieve convergence, the association was calculated by PLINK. OR: Odds Ratio. CIs: confidence intervals. HC: healthy control. CC: case-control. NOS: non-OS.