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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Curr Opin Cell Biol. 2020 Mar 3;65:150–155. doi: 10.1016/j.ceb.2020.01.009

Fig. 3. Removal of the centriolar inhibitory protein Cep215/Cdkrap2 to the mitotic spindle midbody occurs by endocytic membrane trafficking.

Fig. 3.

Centriolar proteins such as Cep215/Cdkrap2 link the procentriole to the mother centriole and prevent premature disengagement and duplication. Vesicular transport provides a mechanism by which endocytic regulatory proteins such as EHD1 can interact with Cep215/Cdkrap2 to facilitate its removal from the centriole to the spindle midbody, thus facilitating centriole disengagement and duplication.