Figure 2.

Percent change in pain ratings from rest to manipulation during noxious heat stimulation and saline (blue) and naloxone (red) infusion (± 95% confidence intervals). Left graph: There were no significant differences in pain intensity reductions between saline and naloxone infusion during mindfulness meditation or slow-paced, breathing. Sham-mindfulness did not reduce pain intensity ratings (p > .4). Right graph: There were no significant differences in pain unpleasantness reductions between saline and naloxone infusion during mindfulness meditation or slow-paced, breathing. *Sham-mindfulness reduced pain unpleasantness ratings during saline infusion but naloxone infusion reversed sham-mindfulness induced pain unpleasantness reductions (p =.02).