Skip to main content
. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Arch Dermatol Res. 2020 Mar 9;312(9):647–656. doi: 10.1007/s00403-020-02059-0

Figure 1. HLA-DRB1 alleles that have the greatest percent of predicted binders among all autoallergens.

Figure 1.

(A) Number of predicted binders for each alleles, expressed as a percent of all epitopes. (*) denotes that the allele was in the top five alleles ranked by percent of predicted binders for the given autoallergen; faded cells indicate that the allele was not in the top five alleles with the most predicted binders for the given autoallergen. Alleles that appeared in the top five for more than one autoallergen are listed, and alleles that overlap between the IEDB and NetMHCIIpan algorithms are bold and italicized. (B) Amino acid sequences at key positions implicated in binding pockets in the antigen presenting domain of the MHC molecule. Residues are categorized as hydrophobic, polar uncharged, negatively charged, and positively charged.