Table 1.
Expression of cell death signaling gene mRNA in the postmortem human AUD hippocampus.
| Gene | Control | AUD | Independent samples t-test statement |
|---|---|---|---|
| Fas | 100 (±22) | 258 (±61)* | t(18) = 2.4, p < 0.05 |
| FasL | 100 (±23) | 285 (±49)*** | t(18) = 3.4, p < 0.01 |
| DR3 | 100 (±18) | 324 (±93)* | t(18) = 2.3, p < 0.05 |
| TL1A | 100 (±25) | 248 (±74) | t(18) = 1.9, p = 0.07 |
| FADD | 100 (±9) | 195 (±37)* | t(18) = 2.5, p < 0.05 |
| TRADD | 100 (±21) | 266 (±87) | t(18) = 1.9, p = 0.08 |
| IL-8 | 100 (±25) | 243 (±68) | t(18) = 0.67, p = 0.52 |
| Caspase 3 | 100 (±20) | 251 (±68)* | t(18) = 2.1, p < 0.05 |
| Caspase 7 | 100 (±19) | 284 (±86)* | t(18) = 2.1, p = 0.05 |
| Caspase 8 | 100 (±20) | 269 (±62)* | t(18) = 2.6, p < 0.05 |
| Caspase 9 | 100 (±24) | 267 (±83) | t(18) = 1.9, p = 0.07 |
| NF-κB p65 | 100 (±19) | 256 (±72)* | t(18) = 2.1, p = 0.05 |
Data are presented as % of moderate drinking controls with mRNA (RT-PCR) values. Presented as mean (±S.E.M.). See Supplementary Table 2 for case characteristics of human subjects.
*p ≤ 0.05, ***p < 0.005.