Table 3:

Associations between genetic variants and objective weight change in a study of etonogestrel implant users

	Objective weight change
	β	95% CI
Genetic Variants
CYP3A5 rs15524*	0.75	−0.71, 2.21
CYP3A4*1G§	0.38	−1.39, 2.16
CYP3A4 rs2246709§	−0.93	−2.09, 0.24
CYP3A4 rs4646440§	1.53	−0.05, 3.09
ESR1 rs9322335*	1.64†	0.27, 3.01
CYP2C19 rs11568732§	−2.82†	−5.62, −0.02
AKR1C3 rs12529*	1.17†	0.03, 2.31
ESR1 rs2077647*	1.29†	0.05, 2.53
ESR1 rs2228480*	2.68†	1.13, 4.24
CYP2C19 rs7088784§	−2.99†	−5.46, −0.52
ESR1 rs9340799*	1.95†	0.34, 3.55

Performed using simple linear regression

^†Statistically significant using p-value cut-off <0.05

^*Genetic variant grouped as participants with two copies of variant allele (homozygous variant) versus all others

^§Genetic variant grouped as participants with at least one copy of the variant allele (carriers) versus all others