Table 1.
Demographics and baseline characteristics of subjects with and without severe acute kidney injury
| Acute Kidney Injury Group |
|||
|---|---|---|---|
| Demographic and baseline characteritics | Absent/Stage 1 AKI (N = 172) | Stage 2/3 AKI (N = 176) | P-value |
| Male | 94 (54.7%) | 92 (52.3%) | 0.6571 |
| Age (years) | 5.7 [1.7, 11.8] | 7.4 [1.5, 13.8] | 0.2432 |
| Race | 0.3841 | ||
| White | 110 (64.0%) | 98 (55.7%) | |
| Black or African American | 30 (17.4%) | 39 (22.2%) | |
| Multiracial | 6 (3.5%) | 6 (3.4%) | |
| Other | 12 (7.0%) | 18 (10.2%) | |
| Unknown or not reported | 14 (8.1%) | 15 (8.5%) | |
| Ethnicity | 0.9611 | ||
| Hispanic or Latino | 42 (24.4%) | 42 (23.9%) | |
| Not Hispanic or Latino | 129 (75.0%) | 131 (74.4%) | |
| Unknown or Not Reported | 1 (0.6%) | 3 (1.7%) | |
| Weight at PICU admission (kg) | 19.1 [11.2, 37.0] | 23.8 [9.8, 49.9] | 0.1932 |
| Height at PICU admission (cm) | 111.0 [80.3, 137.0] | 117.0 [75.5, 150.5] | 0.3902 |
| PRISM (excluding creatinine) | 8.0 [4.0, 14.0] | 12.0 [8.0, 18.5] | <.0012 |
| Medical complexity algorithm category | 0.3221 | ||
| No chronic comorbid conditions | 84 (48.8%) | 88 (50.0%) | |
| Chronic comorbid conditions (non-complex) | 12 (7.0%) | 6 (3.4%) | |
| Chronic comorbid conditions (complex) | 78 (44.2%) | 81 (46.0%) | |
| Immune-related comorbid conditions | |||
| Malignancy | 13 (7.6%) | 8 (4.5%) | 0.2361 |
| Subject immunocompromised | 33 (19.2%) | 32 (18.2%) | 0.8101 |
| Solid organ transplant | 0 (0.0%) | 2 (1.1%) | 0.0981 |
| Bone marrow or stem cell transplantation | 2 (1.2%) | 1 (0.6%) | 0.5451 |
| Sickle cell disease | 2 (1.2%) | 1 (0.6%) | 0.5451 |
| FSS at baseline | 0.3372 | ||
| Good (6 – 7) | 103 (59.9%) | 94 (53.4%) | |
| Mildly abnormal (8 – 9) | 11 (6.4%) | 23 (13.1%) | |
| Moderately abnormal (10 – 15) | 36 (20.9%) | 40 (22.7%) | |
| Severely abnormal (16 – 21) | 19 (11.0%) | 15 (8.5%) | |
| Very severely abnormal (≥ 22) | 3 (1.7%) | 4 (2.3%) | |
| Criteria for AKI diagnosis | |||
| No AKI diagnosis | - | 0 (0.0%) | |
| Serum creatinine | - | 93 (52.8%) | |
| Urine output | - | 28 (15.9%) | |
| Serum creatinine and urine output | - | 55 (31.3%) | |
1
Likelihood ratio test.
2
Wilcoxon rank-sum test.
Abbreviations: AKI, acute kidney injury; FSS, Functional Status Scale; PRISM, Pediatric Risk of Mortality Score; PICU, Pediatric Intensive Care Unit