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. Author manuscript; available in PMC: 2021 Jul 3.
Published in final edited form as: Circ Res. 2020 Apr 9;127(2):e1–e13. doi: 10.1161/CIRCRESAHA.119.316053

Figure 3: Resistance artery endothelial-dependent and -independent dilation in lowlanders at sea level and high altitude.

Figure 3:

Individual and mean data displaying the impact of adrenergic blockade at sea level and high altitude on forearm vascular conductance during acetylcholine (ACh) infusion (panel A), and sodium nitroprusside (SNP) infusion (panel C). Mean summary data (±SD) highlighting the impact of adrenergic blockade on forearm vascular conductance at sea level and high altitude in response to ACh (panel B), and SNP (panel D). Forearm vascular conductance in response to ACh was reduced at high altitude compared to sea level in lowlanders (panel A). Adrenergic blockade increased forearm vascular conductance to ACh at high altitude in lowlanders (panel B). Adrenergic blockade increased forearm vascular conductance to SNP at sea level in lowlanders (panel C). P-values are displayed on each figure panel. Two-way repeated measures (lowlanders: Drug dose x Pre/Post blockade, and Drug dose x Altitude) analysis of variance were used to detect any differences in systemic and forearm hemodynamics.