Skip to main content
. Author manuscript; available in PMC: 2021 Jul 3.
Published in final edited form as: Circ Res. 2020 Apr 9;127(2):e1–e13. doi: 10.1161/CIRCRESAHA.119.316053

Figure 4: Resistance artery endothelial-dependent and -independent dilation in Andean highlanders at high altitude.

Figure 4:

Individual and mean data displaying the impact of adrenergic blockade on forearm vascular conductance during acetylcholine (ACh) infusion (panel A), and sodium nitroprusside (SNP) infusion (panel C) in Andeans with and without EE. Mean summary data (±SD) highlighting the impact of adrenergic blockade on forearm vascular conductance in response to ACh (panel B), and SNP (panel D), in Andeans with and without EE. Forearm vascular conductance to ACh was reduced in Andeans with EE compared to non-EE Andeans (panel A). Adrenergic blockade increased forearm vascular conductance to SNP in non-EE Andeans (Panel D). P-values are displayed on each figure panel. Two-way mixed (highlanders: Drug dose x Pre/Post blockade, and Drug dose x EE/non-EE) analysis of variance were used to detect any differences in systemic and forearm hemodynamics.