. Author manuscript; available in PMC: 2021 Sep 1.

Published in final edited form as: Am J Kidney Dis. 2020 Apr 24;76(3):350–360. doi: 10.1053/j.ajkd.2019.12.014

Table 3:

Univariable and multivariable analysis of clinical exposure variables for hazard of kidney failure in individuals in the Biopsy Biobank Cohort of Indiana

Variable	Univariable Analysis^b			Adj Clinical Model^c
Variable	HR (95% CI)	r²	C	Adj HR (95% CI)	r²	C
Variable
Age, per 1-year older	1.01 (1.01–1.02)^a	0.93%	0.57	0.98 (0.97–0.99)^a
African American race^*	1.80 (1.48–2.20)^a	1.22%	0.56	1.88 (1.53–2.31)^a
Male sex	1.09 (0.90–1.32)	0.03%	0.51	0.97 (0.79–1.18)
CHF	2.87 (2.36–3.48)^a	4.00%	0.62	1.34 (1.07–1.68)^a
PVD	2.47 (1.98–3.09)^a	1.95%	0.56	1.34 (1.05–1.70)^a
Diabetes	2.12 (1.75–2.58)^a	2.10%	0.59	1.16 (0.93–1.46)
Hypertension	1.97 (1.62–2.40)^a	1.71%	0.58	1.26 (1.01–1.56)^a
CAD	2.60 (2.14–3.15)^a	3.28%	0.61	1.36 (1.07–1.72)^a
Smoking history, current or prior	2.02 (1.66–2.45)^a	1.83%	0.59	1.24 (1.00–1.54)^a
Proteinuria	1.05 (1.03–1.06)^a	1.85%	0.65	1.04 (1.03–1.05)^a
Baseline eGFR (per 10 ml/min/1.73m² greater)	0.69 (0.66–0.73)^a	12.85%	0.81	0.85 (0.80–0.92)^a,d
Fully Adjusted model					32.0%	0.912

Based on 411 individuals with the kidney failure outcome (15.1% of total).

Significant comparison with p < 0.05.

Unadjusted hazard ratios by Cox proportional hazard test.

The adjusted clinical model by Cox regression model.

Both the baseline eGFR and time interaction term (eGFR x time) per 365 days were included in the adjusted model.

reference group: ____.

CI – confidence interval, CHF – congestive heart failure, PVD – peripheral vascular disease, CAD – coronary artery disease, Adj – adjusted; C, C-statistic