TABLE 3:
Tissue Histology Analysis.
| Pathology Severity
Scores |
Percent Pathology
Incidence |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Control | (1) Partial ER-REBOA | (2) Partial pREBOA-PRO | p-values | Control | (1) | (2) | p-values | ||
| Liver | Atrophy Centrilobular Cords | 0 (0, 1.5) | 1.5 (0, 1.5) | 1.5 (0.8, 1.5) | 0.772 | 33.3 | 66.7 | 88.9 | 0.256 |
| Necrosis Centrilobular | 0 (0, 0) | 0 (0, 1.3) | 0 (0, 0) | 0.471 | 0.0 | 22.2 | 0.0 | 0.134 | |
| Fibrosis | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | >0.999 | 0.0 | 11.1 | 0.0 | 0.304 | |
| Degeneration Centrilobular | 0 (0, 0) | 1.5 (0, 2.3) | 0 (0, 1.3) | 0.087 | 0.0 | 66.7 | 33.3 | 0.157 | |
| Increased Circulating Neutrophils | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0.206 | 0.0 | 33.3 | 0.0 | 0.058 | |
| Periportal Inflammation | 1 (0, 1) | 1.5 (1.3, 1.5) | 1 (0.5, 1.3) | 0.035 | 66.7 | 100.0 | 77.8 | 0.134 | |
| Neutrophilic inflammation | 0.0 | 77.8 | 22.2 | 0.018 | |||||
| Background Inflammation | 66.7 | 22.2 | 55.6 | 0.147 | |||||
| Subcapsular Inflammation | 0 (0, 0) | 1 (0.5, 1) | 0 (0, 0.5) | 0.057 | 0.0 | 77.8 | 22.2 | 0.018 | |
| Neutrophilic inflammation | 0.0 | 77.8 | 22.2 | 0.018 | |||||
| Background Inflammation | 0.0 | 0.0 | 0.0 | >0.999 | |||||
| Capsulitis, neutrophilic, with fibrin | 0 (0, 0) | 1 (0, 1) | 0 (0, 0) | 0.050 | 0.0 | 66.7 | 11.1 | 0.016 | |
| Hemorrhage | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | >0.999 | 0.0 | 11.1 | 0.0 | 0.304 | |
| Congestion Centrilobular | 0 (0, 0) | 0 (0, 0.8) | 0 (0, 1.8) | 0.327 | 0.0 | 22.2 | 44.4 | 0.317 | |
| Kidney | Tubular Degeneration | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | >0.999 | 0.0 | 0.0 | 0.0 | >0.999 |
| Tubular necrosis | 0 (0, 0) | 0 (0, 0.5) | 0 (0, 1) | >0.999 | 0.0 | 22.2 | 33.3 | 0.599 | |
| Interstitial nephritis | 1 (0, 1) | 0 (0, 1) | 1 (0, 1) | 0.637 | 66.7 | 44.4 | 66.7 | 0.343 | |
| Congestion | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | >0.999 | 0.0 | 0.0 | 11.1 | 0.304 | |
| Small intestine | Overall Inflammation Severity | 1 (1, 2) | 1 (1, 1) | 1 (1, 2) | 0.577 | 100.0 | 100.0 | 100.0 | 1.000 |
| Background Inflammation | 100.0 | 100.0 | 100.0 | 1.000 | |||||
| Edema of Lamina Propria | 2 (2, 2) | 2 (2, 2) | 2 (2, 2) | >0.999 | 100.0 | 100.0 | 100.0 | 1.000 | |
| Muscularis Mucosa inflammation | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | >0.999 | 0.0 | 11.1 | 0.0 | 0.304 | |
| Skeletal muscle, Above | Degeneration | 0 (0, 0) | 0 (0, 2) | 0 (0, 0.5) | 0.577 | 0.0 | 33.3 | 22.2 | 0.510 |
| Necrosis | 0 (0, 1) | 1 (0.5, 2) | 1 (0, 1.5) | 0.388 | 33.3 | 77.8 | 55.6 | 0.317 | |
| Regeneration | 0 (0, 0) | 0 (0, 0.5) | 0 (0, 0) | >0.999 | 0.0 | 22.2 | 11.1 | 0.527 | |
| Skeletal muscle, Below | Degeneration | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.5) | >0.999 | 0.0 | 11.1 | 22.2 | 0.527 |
| Necrosis | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | >0.999 | 33.3 | 44.4 | 44.4 | 1.000 | |
| Regeneration | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | >0.999 | 33.3 | 0.0 | 0.0 | >0.999 | |
Pathology severity scores are reported as medians with interquartile values. Wilcoxon Rank-Sum test was used to compare severity scores and chi2-test was used to compare incidences of pathology in pREBOA-PRO and ER-REBOA groups.
Key: 0 = none, 1 = mild, 2 = moderate, 3 = severe; Background inflammation = lymphoplasmacytic and eosinophilic.