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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Food Chem Toxicol. 2020 Jun 19;143:111512. doi: 10.1016/j.fct.2020.111512

Figure 1. Feeding suppression of raspberry ketone.

Figure 1.

Standard chow was measured following doses of raspberry ketone (RK; 64 mg/kg, 200 mg/kg, and 640 mg/kg) or vehicle in C57Bl/6J (10 weeks old) male and female mice. Data are represented as means ± SEM. A single dose of raspberry ketone was administered by oral gavage in an ascending order in each mouse. There was a 7-day washout between doses. A: Cumulative 24 h intake was measured under ad libitum feeding conditions (n = 10/sex) B: In a separate group of mice, cumulative 24 h intake was measure following a 24 h food deprivation (n = 10/sex). In addition to chow, non-nutritive kaolin was available to assess pica behavior as indicator for nausea. There were no differences in kaolin intake in the doses of raspberry ketone tested. * indicated p < 0.05 from vehicle, ** indicated p < 0.005 from vehicle.