Skip to main content
. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Food Chem Toxicol. 2020 Jun 19;143:111512. doi: 10.1016/j.fct.2020.111512

Figure 2. Conditioned taste aversion (CTA) and 2-bottle preference test to 0.15% saccharin paired with raspberry ketone (400 mg/kg) or vehicle.

Figure 2.

All mice were 10 weeks old at the onset of the experiment. For the CTA, there were 8-session conditioning phase under water-restricted conditions. For 4 sessions, a 60-min access of 0.15% saccharin was paired with oral gavage dosed raspberry ketone (RK; 400 mg/kg) or vehicle. The intervening 4 sessions (non-pairing) were water only. A: Water or saccharin consumption was measured in two testing sessions (60 min) randomly presented in the absence of RK or vehicle. Data are represented as means ± SEM. The two-bottle test occurred 24 h after the CTA test. Mice were not dosed during the 2-bottle test. B: Mice were given one bottle containing water and the other bottle contained 0.15% saccharin for 48 h. All groups were (n = 10). ** indicated p < 0.005 from previously vehicle-paired mice.