Table 1.

Tabulated histopathological score of tissue. Sections were scored for pathological abnormalities on a scale 0–5. A score of 5 indicates the most severe pathology, whereas 0 indicates no noteworthy findings or within range of background. A total of 24 male mice (10-weeks old) received a single dose by oral gavage of vehicle (n = 10) or raspberry ketone (RK; 640 mg/kg; n=14). 4 days post-treatment 6 mice died. No noteworthy findings were found in the vehicle treated animals. Of the 8 mice that survived, 3 were euthanized on Day 2 and 5 were euthanized on Day 4.

	Histological Grade
RK (640 mg/kg)	0	1	2	3	4	5	% Survival
Adipose atrophy, Epididymal^	0	3	3	1	0	0	57.14% (8/14)
Adipose atrophy, Mesenteric	0	1	1	1	5	0
Brain	8	0	0	0	0	0
Heart	8	0	0	0	0	0
Kidney	8	0	0	0	0	0
Liver	8	0	0	0	0	0
Lung	8	0	0	0	0	0
Pancreas	8	0	0	0	0	0
Sciatic Nerve	8	0	0	0	0	0
Skeletal Muscle	8	0	0	0	0	0
Small Intestine	8	0	0	0	0	0
Spinal Cord	8	0	0	0	0	0
Spleen, White Pulp Hypocellularity	3	2	3	0	0	0
Spleen, Red Pulp, EMH	2	0	4	1	1	0
Stomach	8	0	0	0	0	0
Thymus, Involution #	0	0	0	0	3	2

^{^}indicated 1 sample was not of adequate size or quality for pathologist evaluation,

^#indicated 3 samples were not of adequate size or quality for pathologist evaluation. EMH: Extramedullary hematopoiesis.