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. Author manuscript; available in PMC: 2021 Sep 3.
Published in final edited form as: Mol Cell. 2020 Jul 14;79(5):812–823.e4. doi: 10.1016/j.molcel.2020.06.031

Figure 3. The ARE DNA-bound AR/SRC-3/p300 complex density map and segmentation.

Figure 3.

(A) Cryo-EM density map of the ARE DNA-bound AR/SRC-3/p300 complex at resolution ~20 Å. Shown are 4 different angles of the map rotating every 90 degrees. (B) Segmentation of ARE-DNA/AR/SRC-3/p300. Each component was segmented to annotate different proteins: AR, Green; SRC-3, Orange; p300, Blue, respectively. (C) The assembled ARE-DNA/AR/SRC-3/p300 structure with segmented ARE-DNA/AR density (Figure 1B) replacing the AR density. The p300 density mainly interacts with two NTDs of AR and has a small area touches the two LBDs. See also Supplemental Figure 3, 4, 5 and Supplemental Table 1.