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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Cancer Discov. 2020 May 22;10(9):1388–1409. doi: 10.1158/2159-8290.CD-19-1436

Fig. 6. Schematic representation of abnormal splicing via deubiquitination in T-cell leukemia.

Fig. 6.

T cells exhibit physiological levels of USP7 and SRSF6 coupled to normal splicing. Aberrantly high levels of USP7 (illustrated by the larger size of USP7 scheme in the right panel) contribute to high levels of SRSF6 and exon skipping changes in leukemia.