TABLE III.
Lung function values in the 5 latent classes at the end of follow-up
| Feature | Class 1 (multiple sensitization with partially reversible airflow limitation) | Class 2 (multiple sensitization with reversible airflow limitation) | Class 3 (lesser sensitization with reversible airflow limitation) | Class 4 (multiple sensitization with normal lung function) | Class 5 (lesser sensitization with normal lung function) | P value |
|---|---|---|---|---|---|---|
| N (pre-, postbronchodilator) | 211, 190 | 803, 639 | 258, 206 | 622, 456 | 318, 234 | |
| Prebronchodilator | ||||||
| FVC (% predicted) | 111 (102, 121) | 116 (107, 124) | 115 (106, 122) | 127 (119, 137) | 124 (116, 134) | <.001 |
| FEV1 (% predicted) | 94 (84, 107) | 104 (96, 112) | 102 (94, 110) | 119 (111, 127) | 119 (112, 127) | <.001 |
| z score | −0.4 (−1.3, 0.5) | 0.3 (−0.3, 1.0) | 0.2 (−0.4, 0.8) | 1.6 (0.9, 2.2) | 1.6 (1.0, 2.2) | <.001 |
| z score <LLN* | 37 (17.5) | 36 (4.5) | 8 (3.1) | 8 (1.3) | — | <.001 |
| FEV1/FVC (% predicted) | 85 (78, 92) | 90 (83, 95) | 90 (85, 96) | 94 (88, 98) | 96 (92, 100) | <.001 |
| z score | −1.9 (−2.5, −1.0) | −1.4 (−2.1, −0.8) | −1.3 (−1.9, −0.6) | −0.9 (−1.6, −0.3) | −0.7 (−1.2, −0.1) | <.001 |
| z score <LLN | 126 (59.7) | 321 (40.0) | 101 (39.1) | 143 (23.0) | 35 (11.0) | <.001 |
| Postbronchodilator | ||||||
| FVC (% predicted) | 115 (107, 125) | 118 (109, 127) | 115 (107, 123) | 128 (119, 137) | 125 (117, 133) | <.001 |
| FEV1 (% predicted) | 107 (96, 116) | 113 (106, 121) | 109 (102, 118) | 126 (118, 135) | 124 (116, 133) | <.001 |
| z score | 0.6 (−0.3, 1.3) | 1.1 (0.5, 1.7) | 0.7 (0.1, 1.5) | 2.1 (1.5, 2.8) | 2.0 (1.4, 2.7) | <.001 |
| z score <LLN | 10 (5.2) | 7 (1.1) | 2 (1.0) | 3 (0.7) | — | <.001 |
| FEV1/FVC (% predicted) | 93 (87, 99) | 96 (91, 100) | 96 (91, 99) | 99 (94, 102) | 99 (96, 103) | <.001 |
| z score | −1.0 (−1.7, −0.2) | −0.6 (−1.3, 0.1) | −0.6 (−1.2, −0.1) | −0.2 (−0.8, 0.4) | −0.1 (−0.6, 0.5) | <.001 |
| z score <LLN | 52 (27.4) | 85 (13.3) | 30 (14.6) | 29 (6.4) | 7 (3.0) | <.001 |
Note. Data represent the median (25th, 95th percentile) or the number of participants (%).
*
LLN equivalent to a z score of ≤1.64.