Table 1.
Demographics and Clinical Characteristics for Cross-Sectional Cohort (n=428) by APOE Genotype Class
| Characteristic | APOE-ε3ε3 | APOE-ε2+ | APOE-ε4+ | Test Statistic (df), p-value |
|---|---|---|---|---|
| n | 241 | 43 | 144 | |
| Age at Baseline, y, mean (SD) | 75.60 (9.81) | 75.23 (10.28) | 71.19 (9.87) | F: 9.31 (2), p=0.0001 |
| Education, y, mean (SD) | 14.99 (2.71) | 15.33 (2.82) | 15.72 (3.13) | F: 2.88 (2), p=0.058 |
| MMSE, score, median (IQR) | 28 (27–29) | 28 (27–29) | 27 (23–29) | KW: 16.9 (2), p=0.0002 |
| Female sex, No.(%) | 131 (54.13) | 22 (52.38) | 75 (52.08) | χ2 : 0.27 (2), p=0.873 |
| Nonwhite race/ethnicity, No. (%) | 14 (5.81) | 4 (9.3) | 13 (9.03) | Fisher’s Exact: p=0.371 |
| Clinical Dx, No. (%) | χ2 : 57.83 (6), p<0.0001 | |||
| Control | 166 (67.5) | 27 (11.0) | 53 (21.5) | |
| MCI | 47 (47.0) | 13 (13.0) | 40 (40.0) | |
| AD | 17 (27.9) | 1 (1.6) | 43 (70.5) | |
| DUO | 11 (52.4) | 2 (9.5) | 8 (38.1) | |
| Positive PiB status, No. (%) | 80 (33.2) | 8 (18.6) | 93 (64.58) | χ2 : 47.4 (2), p<0.0001 |
| Baseline [11C]PiB SUVR, mean (SD) | 1.54 (0.44) | 1.36 (0.34) | 1.84 (0.5) | F: 28.49 (2), p<0.0001 |
Abbreviations:
Alzheimer’s disease (AD), dementia of unknown origin (DUO), interquartile range (IQR), Kruskall-Wallis (KW) test, standard deviation (SD), mild cognitive impairment (MCI), mini-mental state examination (MMSE), number (No.), Pittsburgh Compound-B (PiB), standard deviation (SD), standardized uptake value ratio (SUVR), years (y).