Table 2.
Subject Demographics and Clinical Characteristics for Longitudinal Subcohort (n=235) by APOE Genotype Class
| Characteristic | APOE-ε3ε3 | APOE-ε2+ | APOE-ε4+ | Test Statistic (df), p-value |
|---|---|---|---|---|
| n | 142 | 28 | 65 | |
| Age at Baseline, y, mean (SD) | 78.9 (8.92) | 75.6 (10.2) | 73.5 (9.23) | F: 7.98 (2), p=0.00045 |
| Education, y, mean (SD) | 15.1 (2.66) | 15.8 (2.80) | 16.1 (3.19) | F: 2.84 (2), p=0.0602 |
| MMSE score, median (IQR) | 29 (27–29) | 28 (27–29) | 28 (26–29) | KW: 4.00 (2), p=0.14 |
| Female sex, No.(%) | 74 (52.11) | 11 (39.29) | 28 (43.08) | χ2 : 2.44 (2), p=0.29 |
| Nonwhite race/ethnicity, No.(%) | 10 (7.04) | 3 (10.71) | 6 (9.23) | Fisher’s Exact: p=0.68 |
| Follow-up period, y, mean (SD) | 4.48 (2.34) | 4.03 (2.40) | 3.39 (1.80) | F: 5.49 (2), p=0.00468 |
| Number of Visits, mean (SD) | 3.23 (0.97) | 3.25 (1.4) | 2.91 (0.84) | F: 2.45 (2), p=0.0889 |
| Clinical Dx., No. (%) | Fisher’s Exact: p<<0.001 | |||
| Control | 119 (68.8) | 19 (11.0) | 35 (20.2) | |
| MCI | 21 (44.7) | 9 (19.1) | 17 (36.2) | |
| AD | 2 (14.3) | 0 (0) | 12 (85.7) | |
| DUO | 0 (0.0) | 0 (0.0) | 1 (100.0) | |
| Globally PiB Positive, No. (%) | 52 (36.62) | 4 (14.29) | 44 (67.69) | χ2 : 28.00 (2), p<<0.001 |
| Baseline [11C]PiB SUVR, mean(SD) | 1.56 (0.40) | 1.33 (0.35) | 1.86 (0.47) | F: 19.03 (2), p<<0.001 |
Abbreviations:
Alzheimer’s disease (AD), dementia of unknown origin (DUO), interquartile range (IQR), Kruskall-Wallis (KW) test, standard deviation (SD), mild cognitive impairment (MCI), mini-mental state examination (MMSE), number (No.), Pittsburgh Compound-B (PiB), standard deviation (SD), standardized uptake value ratio (SUVR), years (y).