Table 4.
Annualized changes in [11C]PiB retention measures by APOE genotype class
| Comparison | APOE-ε3ε3 | APOE-ε2+ | APOE-ε4+ | Test Statistic (df), p-value |
|---|---|---|---|---|
| All Participants | ||||
| n | 142 | 28 | 65 | |
| Change (SUVR/yr), mean (SD) | 0.03(0.05) | 0.04 (0.06) | 0.05 (0.07) | F: 1.74(2), p=0.178a |
| ε3ε3 vs ε2+ | 0.03(0.05) | 0.04 (0.06) | p=0.481b | |
| ε3ε3 vs ε4+ | 0.03(0.05) | 0.05 (0.07) | p=0.103b | |
| ε2+ vs ε4+ | 0.04 (0.06) | 0.05 (0.07) | p=0.574b | |
| Participants PiB+ at Baseline | ||||
| n | 52 | 4 | 44 | |
| Change (SUVR/yr), mean (SD) | 0.05 (0.07) | 0.11 (0.09) | 0.05 (0.08) | |
| Change (SUVR/yr), median (IQR) | 0.06 (0.01–0.10) | 0.08 (0.04–0.18) | 0.06 (0.0–0.10) | KW: 1.19 (2), p=0.551c |
| ε3ε3 vs ε4+ | 0.06 (0.01–0.10) | 0.06 (0.0–0.10) | p=0.936d | |
| Participants PiB- at Baseline | ||||
| n | 90 | 24 | 21 | |
| Change (SUVR/yr), mean (SD) | 0.02 (0.04) | 0.03 (0.04) | 0.04 (0.06) | F: 1.0 (2), 0.369a |
| Change (SUVR/yr), median (IQR) | 0.02 (0.0–0.05) | 0.02 (0.0–0.06) | 0.04 (0.0–0.08) | |
| ε3ε3 vs ε4+ | 0.02 (0.04) | 0.04 (0.06) | p=0.340e | |
| Incident PiB+ participants | ||||
| n | 30 | 3 | 7 | |
| Change (SUVR/yr), mean (SD) | 0.06 (0.03) | 0.09 (0.03) | 0.09 (0.03) | |
| Change (SUVR/yr), median (IQR) | 0.06 (0.04–0.08) | 0.10 (0.05–0.11) | 0.09 (0.06–0.12) | KW: 6.24(2), 0.044c |
| ε3ε3 vs ε4+ | 0.06 (0.04–0.08) | 0.09 (0.06–0.12) | p=0.029d | |
a
p-value from one-way ANOVA
b
p-value from paired t-test
c
p-value from Kruskall-Wallis test
d
p-value from non-parametric Wilcoxon test
e
p-value from independent two sample t-test