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. 2020 Sep 10;3:501. doi: 10.1038/s42003-020-01234-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a At stage 17 NogginA is expressed in the caudal chordamesoderm. b, c At stage 19 expression is in the entire chordamesoderm except for its most anterior part and in the dorsal region of the presumptive brain, excluding the most anterior part. d At stage 22 expression is in the floor and roof plate of the neural tube, in the notochord, in the somites, in the cheek process and in the diencephalon, midbrain and hindbrain. e–j At stages 23–25 expression pattern includes somites (i, j), upper and lower lips (g), notochord, in several areas of the brain: at the border of telencephalon and diencephalon, in zona limitans intrathalamica, at mid-hind brain boundary and in the hindbrain (g, i). k, l At stage 18 NogginC is expressed in the 2 chordamesoderm regions: anterior part and caudal part. m At stage 22 NogginC is found in the notochord, neural tube, pharyngeal arches, otic pits, cheek process and somites. n At stages 24 the expression of NogginC appears in the forebrain and otic visicles, upper and lower lips. o–q At stages 25 the cells of the pineal gland (transverse section on P) also express NogginC. r NogginC expression in somites at stage 25. s, t At stage 17 NogginD is expressed in the neural tube. u, v At stage 17 the expression of NogginD develops throughout the neural system in a diffuse manner and weakly in somites. as anterior intraencephalic sulcus, ch optic chiasma; di diencephalon, e eye, fb forebrain, h hindbrain, hb habenula, hpt hypothalamus, ll lower lip, ul upper lip, mes mesencephalon, MHB mid-hindbrain boundary, n notochord, ncc neural crest cells, np neural plate, nt neural tube, oc otic cup, op olfactory placode, pg pineal gland, pha pharyngeal arche, tel telencephalon, ZLI zona limitans intrathalamica.