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. 2020 Sep 10;10:14906. doi: 10.1038/s41598-020-72023-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of TMF treatment on apparent diffusion coefficient (ADC) values (A) Mean ADC values were measured in the ipsilateral ischaemic core (IC, red square), peri-infarct region (PIR, green square), anterior choroidal and hypothalamic region (AHR, blue square), and contralateral regions on ADC maps during the follow-up period. (B) Combined relative ADC (rADC) values immediately after ischaemia were decreased in groups with induced ischaemia. (C,D) The rADC values of the (C) IC and (D) PIR were plotted against time. Data are represented as means ± SDs (n = 8 rats in each group). *P < 0.05 vs. sham group; **P < 0.001 vs. sham group; ^#P < 0.05 vs. control group; ^##P < 0.001 vs. control group.