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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Neurosci Biobehav Rev. 2020 May 30;115:116–130. doi: 10.1016/j.neubiorev.2020.05.016

Table 2.

The effects of ceftriaxone on xCT expression

Reference(s) Model Species/strain Brain region (s) xCT increased by Ceftriaxone?
Lewerenz et al., 2009 Cell culture HT22 cells n/a Yes: 300 μM (7 days) increases system xc-activity
Krzyzanowska et al., 2016 Healthy rats Male Wistar rats Dorsal striatum Yes: 200 mg/kg for 8 days
Krzyzanowska et al., 2016 Healthy rats Male Wistar rats Frontal cortex, Hippocampus No: 200 mg/kg for 8 days
Garcia et al., 2019; Knackstedt et. al., 2010 Healthy rats Male Sprague Dawley rats NA core No: 200 mg/kg for 5 days
Krzyzanowska et al., 2016 Cerebral ischemia (MCAO) Male Wistar rats Frontal cortex Yes (mRNA): 200 mg/kg for 5 days
Krzyzanowska et al., 2017 Cerebral ischemia (MCAO) Male Wistar rats Frontal cortex (astrocytes and neurons) No: ↓ after 200 mg/kg for 5 days MCAO
Bechard et al., 2018; Knackstedt et. al., 2010; LaCrosse et al., 2017; Schwendt et al., 2018 Cocaine relapse Male Sprague Dawley rats NA core Yes: 200 mg/kg for 5–7 days
Niedzielska-Andres et al., 2019 Cocaine CPP Male Wistar rats Dorsal striatum Yes: 200 mg/kg for 7 days
Althobaiti et al., 2016 Non-contingent METH Male Wistar rats NA and mPFC Yes: 200 mg/kg for 2 days
Alhaddad et al, 2014; Das et al, 2015; Rao et al, 2015; Sari et al, 2011 Alcohol consumption Male P rats NA core; PFC Yes: 100 and 200 mg/kg but not 50 mg/kg
Stennett et al., 2017 Alcohol consumption Male Sprague Dawley rats NA core Yes: 200 mg/kg
Alshehri et al, 2018 Hydrocodone CPP Male P rats NA, Hipp, but not PFC or amygdala Yes: 200 mg/kg

CPP- conditioned place preference, Hipp- hippocampus, MCAO- middle cerebral artery occlusion, METH- methamphetamine, mPFC- medial prefrontal cortex, n/a- not applicable, NA- nucleus accumbens, PFC- prefrontal cortex.