Table 2.
Reference(s) | Model | Species/strain | Brain region (s) | xCT increased by Ceftriaxone? |
---|---|---|---|---|
Lewerenz et al., 2009 | Cell culture | HT22 cells | n/a | Yes: 300 μM (7 days) increases system xc-activity |
Krzyzanowska et al., 2016 | Healthy rats | Male Wistar rats | Dorsal striatum | Yes: 200 mg/kg for 8 days |
Krzyzanowska et al., 2016 | Healthy rats | Male Wistar rats | Frontal cortex, Hippocampus | No: 200 mg/kg for 8 days |
Garcia et al., 2019; Knackstedt et. al., 2010 | Healthy rats | Male Sprague Dawley rats | NA core | No: 200 mg/kg for 5 days |
Krzyzanowska et al., 2016 | Cerebral ischemia (MCAO) | Male Wistar rats | Frontal cortex | Yes (mRNA): 200 mg/kg for 5 days |
Krzyzanowska et al., 2017 | Cerebral ischemia (MCAO) | Male Wistar rats | Frontal cortex (astrocytes and neurons) | No: ↓ after 200 mg/kg for 5 days MCAO |
Bechard et al., 2018; Knackstedt et. al., 2010; LaCrosse et al., 2017; Schwendt et al., 2018 | Cocaine relapse | Male Sprague Dawley rats | NA core | Yes: 200 mg/kg for 5–7 days |
Niedzielska-Andres et al., 2019 | Cocaine CPP | Male Wistar rats | Dorsal striatum | Yes: 200 mg/kg for 7 days |
Althobaiti et al., 2016 | Non-contingent METH | Male Wistar rats | NA and mPFC | Yes: 200 mg/kg for 2 days |
Alhaddad et al, 2014; Das et al, 2015; Rao et al, 2015; Sari et al, 2011 | Alcohol consumption | Male P rats | NA core; PFC | Yes: 100 and 200 mg/kg but not 50 mg/kg |
Stennett et al., 2017 | Alcohol consumption | Male Sprague Dawley rats | NA core | Yes: 200 mg/kg |
Alshehri et al, 2018 | Hydrocodone CPP | Male P rats | NA, Hipp, but not PFC or amygdala | Yes: 200 mg/kg |
CPP- conditioned place preference, Hipp- hippocampus, MCAO- middle cerebral artery occlusion, METH- methamphetamine, mPFC- medial prefrontal cortex, n/a- not applicable, NA- nucleus accumbens, PFC- prefrontal cortex.