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. 2020 Aug 28;11:2024. doi: 10.3389/fimmu.2020.02024

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Copyright © 2020 Yin, Fan, Xu, Wu, Li, Zhou, Liao, Duan, Wang, Geng and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The suppressive roles of EVs in lung cancer immunity. Lung tumor–derived exosomes and microparticles can suppress antitumor immunity in various ways. Activated T-cells release microparticles, which induce their own death via Fas/FasL signaling. TEXs, Lung tumor-derived exosomes; TMPs, tumor-derived microparticles; LMPs, T-lymphocyte-derived microparticles; TAN, tumor-associated neutrophil; AICD, activation-induced cell death; MDSCs, Myeloid-derived suppressor cells; M1/2, macrophages subtype 1/2. Figure created with BioRender.com.