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. 2020 Aug 28;11:2024. doi: 10.3389/fimmu.2020.02024

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Copyright © 2020 Yin, Fan, Xu, Wu, Li, Zhou, Liao, Duan, Wang, Geng and Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The applications of EVs in lung cancer therapy. (A) Modified lung cancer cells, dendritic cells, or embryonic stem cell–derived extracellular vesicles can be used to stimulate antitumor immunity as vaccines. Modified T-cells or macrophage-derived extracellular vesicles can potentially inhibit proliferation of lung cancer cells. (B) Blocking the release of exosomes from lung cancer cells (TEXs) or neutralizing the immunosuppressive molecules on TEXs are potentially effective antitumor ways. ?, uncertain; MAGE, melanoma antigen gene; GM-CSF, granulocyte-macrophage colony-stimulating factor; MTX, methotrexate; OVs, Oncolytic virus; TMPs, lung tumor-derived microparticles; TEVs, EVs from lung tumor cells; TEXs, Lung cancer-derived exosomes; DEXs, exosomes from dendritic cells; ESEVs, EVs from embryonic stem cells; LMPs, T-lymphocyte-derived microparticles; MEXs, exosomes derived from macrophages; DMA, Dimethyl amiloride; HSP72, Heat Shock Protein 72; TLR2, toll-like receptor 2. Figure created with BioRender.com.