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. Author manuscript; available in PMC: 2021 Jul 15.
Published in final edited form as: J Proteomics. 2020 May 20;223:103826. doi: 10.1016/j.jprot.2020.103826

Fig. 2.

Fig. 2.

Proteins with significant and > 20-fold change in the immediate microenvironment of the islet allografts during progression of rejection as revealed by localized proteomics in longitudinal aqueous humor samples. (A,B) Soluble proteins showing > 20-fold (A) increase or (B) decrease in abundance relative to baseline before the transplant (Pre-TX) in longitudinal aqueous humor samples collected during the progression of rejection of ACE-transplanted allogeneic islets. Protein levels were measured by LC-MS/MS in the individual samples collected at the various phases of rejection (Pre-Onset, Onset, and Post-Onset) from recipient mice (n = 5) and normalized to the corresponding protein levels in baseline samples obtained from each mouse before the islet transplant (Pre-TX). (C) Venn diagrams showing the overlap in the proteins identified in the Pre-Onset, Onset, and Post-Onset phases of rejection that showed (left) a ≥ 4–20-fold increase and (right) > 20-fold increase in the Post-Onset phase compared to Pre-TX.