Table 1.

Risk-equivalent age for clinically significant prostate cancer^§, by polygenic hazard score (PHS) percentile.

PHS percentile	Age when man reaches 50-year-standard riskα [95% CI]	ΔAgeβ [95% CI]
1	60 [59, 62]	−10 [−11, −8]
5	56 [54, 58]	−6 [−8, −4]
20	53 [51, 55]	−3 [−5, −1]
50	50 [48, 52]	0 [−2, 2]
80	47 [45, 48]	3 [1, 4]
95	44 [43, 46]	6 [5, 8]
99	41 [39, 43]	9 [7, 11]

^§Clinically significant prostate cancer was defined as Gleason score ≥7, clinical stage T3–T4, PSA ≥10, or with nodal/distant metastases.

^αRisk of typical 50-year-old defined as overall population incidence at age 50.

^βΔAge = difference between 50 and the age when risk is that of a typical 50-year-old man.